Blood vessel dilation in the eye (ocular hyperemia).Postoperative iris inflammation ( iritis) after cataract extraction.Persistent swelling of cornea ( bullous keratopathy).Congestion of blood vessels in the conjunctiva, the clear membrane over the whites of the eye and inner eyelid surfaces ( conjunctival vascular congestion).Deposits in the middle layer of the cornea (corneal granularity).Difficulty with sight in low light conditions.Accommodative spasm, a condition caused by a spasm of the ciliary muscle that makes the eye constantly focus on near objects.Corneal decompensation, a condition in which the innermost corneal layer ( endothelium) is affected and can cause corneal opacity.Corneal edema (corneal swelling-buildup of fluid in your cornea).Side effects of ophthalmic direct-acting miotics may include the following: What are side effects of ophthalmic direct-acting miotics? Balancing the inflow and outflow of aqueous humor is necessary to maintain optimum pressure in the eye and the eye’s spherical shape. Ophthalmic direct-acting miotics are used to contract the eye’s ciliary muscle and the sphincter muscle encircling the iris, which constricts the pupil, improves aqueous humor drainage and reduces intraocular pressure. Acetylcholine is a chemical ( neurotransmitter) that nerve endings in muscles secrete to stimulate muscle contraction. Ophthalmic direct-acting miotics mimic acetylcholine and stimulate protein molecules known as cholinergic receptors on the eye muscles that contract in response to acetylcholine. Aqueous humor is a clear fluid that fills the space between the lens and the cornea in the eyes. Miosis improves drainage of aqueous humor and reduces the pressure inside the eye ( intraocular pressure). Ophthalmic direct-acting miotics are medications that cause constriction ( miosis) of pupils by stimulating certain eye muscles to contract. What are ophthalmic direct-acting miotics and how do they work?
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